Complete 1,3 Asymmetric Induction into 3-Methyl-4-(3-Acetylpyrrol-1-yl)Butanal to 1-Acetyl-6-Methyl-8-Hydroxy-5,6,7,8-Tetrahydroindolizine Cyclization
Academic Article
Publication Date:
2006
abstract:
The formation of 1-acetyl-6-methyl-8-hydroxy-5,6,7,8-tetrahydroindolizine (3) from 3-methyl-4-(3-acetylpyrrol-1-yl)butanal (2), coming from the rhodium catalyzed hydroformylation of 2-methyl-3-(3-acetylpyrrol-1-yl)prop-1-ene (1), is reported. Evidences for both the complete diastereoselective cyclization of 2 and configuration determination in 3 via 1H, 13C and IR spectra are reported.
Iris type:
01.01 Articolo in rivista
Keywords:
1; 3-asymmetric induction; hydroformylation; hydroxytetrahydroindolizines; rhodium-catalyst; pyrrolylbutanal
List of contributors:
Alagona, Giuliano; Settambolo, Roberta
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