Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases
Academic Article
Publication Date:
2018
abstract:
Background: There is mounting urgency to find new drugs for the treatment of neurodegenerative disorders. A large number of reviews have exhaustively described either the molecular or clinical aspects of neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's (PD). Conversely, reports outlining how known drugs in use for other diseases can also be effective as therapeutic agents in neurodegenerative diseases are less reported. This review focuses on the current uses of some copper(II) chelating molecules as potential drug candidates in neurodegeneration.
Iris type:
01.01 Articolo in rivista
Keywords:
Clioquinol; metformin; copper; neurodegenerative diseases; drug repurposing; metallostasis; cyclodipeptides
List of contributors:
DI NATALE, Giuseppe; Pappalardo, Giuseppe; Milardi, Danilo; Lanza, Valeria
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