CYCLOHEXANONE MONOOXYGENASE CATALYZED OXIDATION OF METHYL PHENYL SULFIDE AND CYCLOHEXANONE WITH MACROMOLECULAR NADP IN A MEMBRANE REACTOR

Methyl phenyl sulfide and cyclohexanone were oxidized to (R)- methyl phenyl sulfoxide and caprolactone by cyclohexanone monooxygenase. The reactions were carried out in a membrane reactor with the use of the macromolecular coenzyme poly (ethylene glycol)-NADP. Coenzyme regeneration was carried out with the 2-propanol/alcohol dehydrogenase system.