A salivary chitinase of Varroa destructor influences host immunity and mite's survival

Author summary: Varroa destructor is a parasitic mite of honey bees and a major driver of honey bee colony losses. The feeding mites inject a salivary blend of poorly known molecules, which regulate host physiology. Here, we have identified in silico putative host regulation factors occurring in Varroa saliva and characterized the functional role of a highly expressed chitinase, which is conserved across different evolutionary lineages of parasitic arthropods. This enzyme influences host immune response and mite's survival. An in-depth functional analysis of Varroa saliva will shed light on parasitism evolution in arthropods and will pave the way towards the development of new bioinspired strategies for mite control.