Fast and clean borylation of aryl halides under flow using sol-gel entrapped silia cat DPP-Pd

The fast and clean synthesis of boronic acid pinacol esters starting from aryl halides and bis(pinacolato)diboron is heterogeneously carried out over the SiliaCat DPP-Pd solid catalyst with largely enhanced reaction rate and catalyst stability. This opens the route to the transfer of cross-coupling borylation in a flow microreactor from the research level to process development.