Temperature-rate profiles by polarimetric variable-temperature kinetic experiments to study racemization reactions

The racemization of (-)-adrenaline was followed by polarimetric variable-temperature kinetic experiments obtaining activation parameters and k(0bs)(T) profile in one tenth of the time usually spent for traditional kinetic runs. A polarimeter connected to a computer for the acquisition and processing of the analytical data was used. The kinetic profiles were processed by both an integral method and a differential method. The results are in good agreement with each other and with those obtained by constant-temperature kinetics. (C) 2002 Elsevier Science B.V. All rights reserved.