Publication Date:
2014
abstract:
In some tumours, despite a wild-type p53 gene, the p53 pathway is inactivated by alterations in its regulators or by unknown mechanisms, leading to resistance to cytotoxic therapies. Understanding the mechanisms of functional inactivation of wild-type p53 in these tumours may help to define prospective targets for treating cancer by restoring p53 activity.
Iris type:
01.01 Articolo in rivista
Keywords:
ccRCC; drug resistance; TRIM8; cisplatin; nutlin 3; p53
List of contributors:
Valletti, Alessio; Marzano, Flaviana; Tullo, Apollonia; Pesole, Graziano; Caratozzolo, MARIANO FRANCESCO; Sbisa', Elisabetta
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