Controlling polymorphism with membrane-based crystallizers: application to form I and II of paracetamol

In a previous paper, we reported that the fine control of the solvent evaporation rate in membrane crystallizers allows us to modulate the rate of achievement of supersaturation. This induced the selective crystallization of either stable or metastable polymorph of glycine, by switching between a thermodynamic and a kinetic control of the nucleation stage. Here, we studied the polymorphic yield of the membrane crystallized paracetamol.