Function/structure correlation in novel pH-dependent cationic liposomes for glioma cells transfection in vitro

Cationic liposomes are good candidates as gene carriers in cell biology due to their ability to bind DNA through electrostatic interactions. These molecules are used as non-viral delivery systems in the gene therapy of glioma. pH-dependency and transfection efficiency of seven novel lipids (MORF-1, MORF-2, MORF-3, PIPR-1, PIPR-2, MM54 and DC-Amy) were studied. Two of these molecules (PIPR-2 and MM54) show a better transfection efficiency than that of some commercially available liposomes.