Oxylipins from Dracontium loretense

Four novel oxylipins (1-4) were isolated from the n-butanol extract of the corms of Dracontium loretense. Their structures were assigned by 1D and 2D NMR analyses and electrospray ionization multistage ion trap mass spectrometry (ESIITMSn) data. Relative configurations were assigned on the basis of combined analysis of homonuclear and heteronuclear 2,3J couplings, along with ROE data. Oxylipin 2 exhibited an immunostimulatory effect on human PBMC proliferation.