Aging and biomarkers: Transcriptional levels evaluation of Osteopontin/miRNA-181a axis in hepatic tissue of rats in different age ranges
Academic Article
Publication Date:
2020
abstract:
Osteopontin (OPN), a novel hepatic damage marker, as well as several non-coding RNA seem to be associated with liver aging, a little studied and not yet defined process. The aim of the study was to evaluate the expression variations of OPN and miRNA-181a, the transcriptional profiling of long non coding (lnc) RNA GAS-5/miRNA-222 axis and lncRNA NEAT-1 in liver tissue of rats. In addition, to monitor the senescence process, the telomere shortening and TERT/TERC gene expression were also measured.
Iris type:
01.01 Articolo in rivista
Keywords:
Aging; Osteopontin; miRNA; Long non-coding RNA; Telomeres
List of contributors:
DEL RY, Silvia; Sabatino, Laura; Burchielli, Silvia; Caselli, Chiara; Cabiati, Manuela
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