Progress in the Understanding of Drug-Receptor Interactions, Part 2: Experimental and Theoretical Electrostatic Moments and Interaction Energies of an Angiotensin II Receptor Antagonist (C30 H30 N6 O3 S)

Drug-receptor interactions: A combined experimental and theoretical charge density study of an AT1 selective angiotensin II receptor antagonist named LR-B/081 is presented, focusing on electrostatic properties such as molecular electrostatic moments up to the fourth rank and the energies of intermolecular interactions. In this way, the key pharmacophoric features responsible for the high activity of LR-B/081 are elucidated and quantitatively characterised.