Publication Date:
2020
abstract:
Epigenetic reprogramming is emerging as a key mechanism for metastasis development.Our study identifed a novel regulatory mechanism whereby promoter methylation-mediated epigenetic silencing of the gene encoding the ubiquitin ligase subunit F-box/LRR-repeat protein 7 (FBXL7) induces accumulation of active c-SRC, which, in turn, activates epithelial-to-mesenchymal transition and supports cancer cell invasion and metastasis.
Iris type:
01.01 Articolo in rivista
Keywords:
Epigenetics; metastasis; epithelial-to-mesenchymal transition; ubiquitin ligase; c-SRC
List of contributors:
Moro, Loredana
Published in: