Synthesis of conformationally restricted and optically pure analogues of serine-proline dipeptide via aldolic condensation

Academic Article
Publication Date:
2004
abstract:
Parallel synthesis of a small library of hydroxy functionalized bicyclic lactams with optically pure mimicking dipeptide Pro-Ser has been accomplished via aldol condensation of aldehyde 9 with N-BocGlyCO(2)Et. The configurations of eight scaffolds were established unambiguously by NMR spectroscopy
Iris type:
01.01 Articolo in rivista
Keywords:
lactams; bicyclic compounds; peptidomimetics; asymmetric synthesis; aldol reaction
List of contributors:
Handle:
https://iris.cnr.it/handle/20.500.14243/29257
Published in:
SYNTHESIS (STUTTG.)
Journal