Protective effects of equimolar mixtures of monomer and dimer of dehydrozingerone with alpha-tocopherol and/or ascorbyl palmitate during bulk lipid autoxidation

Protective effects of recently synthesised dehydrozingerone, M, OH (which is one half of the molecule of curcumin) and dimer of dehydrozingerone, D-1(OH)(2), as individual compounds (1 mM) and as equimolar binary (1:1) and ternary (1:1:1) mixtures with alpha-tocopherol (TOH) and/or ascorbyl palmitate (AscPH), were studied during bulk lipid autoxidation at 80 degrees C. The highest oxidation stability of lipid substrate, in the presence of individual compounds, was found for TOM, followed by D-1(OH)(2) and KOH, determined from the main kinetic parameters (antioxidant efficiency, reactivity and capacity). AscPH did not show any protective effect. Synergism was obtained for the binary mixtures of (TOH + AscPH) [42.4%], (M1OH + TOH) [32.4%] and (KOH + AscPH) [35.6%] and for the ternary mixture of (M-1-OH + TOH + AscPH) [28.7%]. Different protective effects observed were explained on the basis (of results) of TOH regeneration and its content determined by HPLC. These antioxidant binary and ternary mixtures can be used as functional components of foods with health-promoting effects. (C) 2014 Elsevier Ltd. All rights reserved.