Protective effects of radiofrequency on Beta-amyloid-induced toxicity in human neuroblastoma cells

This study aims to investigate the capability of pre-exposure to 1950 MHz to protect from the amyloid beta (Abeta)-induced cytotoxicity in human neuroblastoma SH-SY5Y cells. Pre-exposure to radiofrequency (RF) reduced of about 30% the Abeta-induced DNA damage, while RF exposure alone did not affect DNA integrity, as assessed by the alkaline comet assay. Moreover, pre-exposure to RF increased microRNA 107, affecting the enzyme responsible for the Abeta plaques deposition BACE1 and decreased the expression of microRNAs related to long term potentiation and excito-toxicity (miRNA335 and miRNA26b). On the woole, RF seems to induce a protective effect against the damage induced by Abeta in human neuroblastoma cells.