In vitro inhibitory effects of Sardinian Pistacia lentiscus L. and Pistacia terebinthus L. on metabolic enzymes: Pancreatic lipase, alfa-amylase, and alfa-glucosidase

Pancreatic triacylglycerol lipase (PL), alfa-amylase, and alfa-glucosidase are appealing pharmacological targets for the management of dyslipidemia, atherosclerosis, and obesity-diabetes. Presently, in vitro screening for considerable inhibition of these digestive hydrolases by endemic Sardinian Pistacia lentiscus L. and P. terebinthus L. leaves and fruits aqueous extracts (AEs) (Anacardiaceae) was undertaken. The AEs PL-IC50 (µg/mL) in an ascending order were: P. lentiscus leaves; 6.1 ± 0.2