Fischer-type alkyl(hydrazino)carbene complexes: new synthetic potential in comparision with aminocarbene complexes.
Academic Article
Publication Date:
2001
abstract:
A general picture is given of the reactivity of the two Fischer-type alkyl(hydrazino)carbene complexes (CO)5CrC(CH3)-
N(Bn)N(CH3)2 (1) and (CO)4CrC(CH3)N(Bn)N
¸¹¹¹¹¹¹¹¹¹º
(CH3)2 (3). Unlike their organic isolobal hydrazide analogues, they easily yield
the corresponding a-anions at 78°C, which react with various electrophiles. Furthermore, the tetracarbonyl chelate 3 (easily generated from 1) has greater synthetic potential than aminocarbenes: for example, it can be alkylated stepwise twice in the a-position, thus making it possible to introduce a new stereogenic centre in the molecule.
N(Bn)N(CH3)2 (1) and (CO)4CrC(CH3)N(Bn)N
¸¹¹¹¹¹¹¹¹¹º
(CH3)2 (3). Unlike their organic isolobal hydrazide analogues, they easily yield
the corresponding a-anions at 78°C, which react with various electrophiles. Furthermore, the tetracarbonyl chelate 3 (easily generated from 1) has greater synthetic potential than aminocarbenes: for example, it can be alkylated stepwise twice in the a-position, thus making it possible to introduce a new stereogenic centre in the molecule.
Iris type:
01.01 Articolo in rivista
Keywords:
Hydrazino carbenes; Hydrazides; Alkylation; Chelate Fischer carbenes
List of contributors:
Baldoli, Clara
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