Applications of NMR to thermostable proteins

Thermostable proteins have always been of significant interest in several
scientific areas. In the last decade, the developments in the field of molecular
and structural biology have offered important insights into the determinants of
protein thermostability. Following an introductory section on thermostable
proteins, extremophilic organisms and the determinants of protein thermostability,
this chapter covers applications of NMR to the study of thermoresistant
proteins. Particular attention has been paid to papers dealing with
structural comparisons between proteins from thermophilic micro-organisms
and their corresponding mesophilic counterparts, the structure–function
relationships of proteins from thermophilic sources and the factors involved in
protein thermostability. The data reported, highlight the accepted assumption
that there is not a single determinant of protein thermostability, rather an
optimal occurrence of several factors