Publication Date:
2010
abstract:
An analytical solution for solving the transient drug diffusion in adjoining porous wall layers faced with a
drug-eluting stent is presented. The endothelium, intima, internal elastic lamina and media are all treated
as homogeneous porous media and the drug transfer through them is modelled by a set of coupled partial
differential equations. The classical separation of variables method for a multi-layer configuration is used.
The model addresses the concept of penetration depth for multi-layer solids that is useful to treat the
wall thickness by estimating a physical bound for mass diffusion. Drug concentration level and mass profiles in each layer at various times are given and discussed.
drug-eluting stent is presented. The endothelium, intima, internal elastic lamina and media are all treated
as homogeneous porous media and the drug transfer through them is modelled by a set of coupled partial
differential equations. The classical separation of variables method for a multi-layer configuration is used.
The model addresses the concept of penetration depth for multi-layer solids that is useful to treat the
wall thickness by estimating a physical bound for mass diffusion. Drug concentration level and mass profiles in each layer at various times are given and discussed.
Iris type:
01.01 Articolo in rivista
Keywords:
Mass transfer; multi-layered porous media; advection-diffusion equation; penetration depth; drug delivery
List of contributors:
Pontrelli, Giuseppe
Published in: