Publication Date:
2019
abstract:
Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in
inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several
tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is
a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions.
The IL-33/ST2 axis plays an important role in several acute and chronic inflammatory diseases,
including asthma and rheumatoid arthritis. Different disorders are related to the activity of IL-33,
ST2, or their axis, including cardiovascular disease or renal disturbances. Therefore, in the present
work, a literature review was conducted, covering the period from 1 January 2000 to 30 November
2018, in PubMed, ScienceDirect, and Google Scholar database, to assess the involvement of the
IL-33/ST2 axis in diabetic kidney disease. 6 articles directly dealing with the argument were
identified, highlighting a clear link between IL-33/ST2 axis and diabetic kidney disease or related
nephropathy. Overall, the involvement of ST2 seems to be more predictive than IL-33, especially in
investigating the deterioration of kidney function; however, both compounds are pivotal in the field
of renal diseases. Future studies are required to confirm the scientific evidences on larger and more
heterogeneous cohorts.
inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several
tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is
a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions.
The IL-33/ST2 axis plays an important role in several acute and chronic inflammatory diseases,
including asthma and rheumatoid arthritis. Different disorders are related to the activity of IL-33,
ST2, or their axis, including cardiovascular disease or renal disturbances. Therefore, in the present
work, a literature review was conducted, covering the period from 1 January 2000 to 30 November
2018, in PubMed, ScienceDirect, and Google Scholar database, to assess the involvement of the
IL-33/ST2 axis in diabetic kidney disease. 6 articles directly dealing with the argument were
identified, highlighting a clear link between IL-33/ST2 axis and diabetic kidney disease or related
nephropathy. Overall, the involvement of ST2 seems to be more predictive than IL-33, especially in
investigating the deterioration of kidney function; however, both compounds are pivotal in the field
of renal diseases. Future studies are required to confirm the scientific evidences on larger and more
heterogeneous cohorts.
Iris type:
01.01 Articolo in rivista
Keywords:
alarmin; chronic kidney disease; diabetes mellitus; IL-33; renal disease; ST2
List of contributors:
Tonacci, Alessandro
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