Impact of phosphorylation on the encapsulation of nucleoside analogues within porous iron(III) metal-organic framework MIL-100(Fe) nanoparticles
Academic Article
Publication Date:
2013
abstract:
Encapsulation of azidothymidine (AZT) or its phosphorylated derivatives (AZT-MP and AZT-TP) has been
performed using nanoparticles of the porous crystalline iron(III) trimesate metal-organic framework
MIL-100(Fe). The number of phosphate groups per nucleoside analogue has a high impact on the drug
loading capacity, and their interaction with the Lewis acid sites from the nanoMOFs is also discussed
through a combination of techniques such as UV-vis absorption, circular dichroism, isothermal titration
calorimetry, HPLC and molecular simulations. Finally, the effect of the differences in terms of host-guest
interactions is discussed through the release in physiological buffers of AZT, AZT-MP and AZT-TP. New
perspectives for the nanoencapsulation of monophosphorylated nucleoside analogues for effective
anti-cancer and anti-viral therapies are then discussed.
performed using nanoparticles of the porous crystalline iron(III) trimesate metal-organic framework
MIL-100(Fe). The number of phosphate groups per nucleoside analogue has a high impact on the drug
loading capacity, and their interaction with the Lewis acid sites from the nanoMOFs is also discussed
through a combination of techniques such as UV-vis absorption, circular dichroism, isothermal titration
calorimetry, HPLC and molecular simulations. Finally, the effect of the differences in terms of host-guest
interactions is discussed through the release in physiological buffers of AZT, AZT-MP and AZT-TP. New
perspectives for the nanoencapsulation of monophosphorylated nucleoside analogues for effective
anti-cancer and anti-viral therapies are then discussed.
Iris type:
01.01 Articolo in rivista
List of contributors:
Anand, Resmi; Monti, Sandra
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