Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity

6A,6B-Dideoxy-6A,6B-di[(N-salicylidene)amino]-b-cyclodextrin was synthesized and characterized by NMR, UV and CD spectroscopy in order to prepare a N,N0-bis-(salicylidene)ethane-1,2-diamine (SalenH2) type ligand. The manganese(III) complex was synthesized and characterized by UV and cyclic voltammetry and compared to EUK-8. The superoxide dismutase (SOD)-like and catalase-like activities were tested by indirect assay. The cyclodextrin complex shows a larger solubility than EUK-8 and good SOD-like activity. Catalase activity is also shown.