Beyond the growth delay in children with sleep-related breathing disorders: a systematic review.
Academic Article
Publication Date:
2020
abstract:
INTRODUCTION:
The availability of high-quality studies on the association between sleep-disordered breathing in children and delayed growth associated with the hormonal profile recorded before surgery and at follow-up is limited.
EVIDENCE ACQUISITION:
Medline PubMed, Scopus and WebOfScience databases were searched for relevant publications published between January 2008 to January 2020 and a total of 261 potentially eligible studies were identified.
EVIDENCE SYNTHESIS:
Following review 19 papers were eligible for inclusion: seven reported a significant post- surgical increase in growth regardless of initial weight status, type of surgery, type of study design, and length of follow-up period. The only high-quality study was a randomized controlled trial that found an increased risk of OSAS relapse in overweight children. Twelve studies reported the significant increase in growth parameters showing that IGF-1, IGFBP-3, and ghrelin may boost growth after surgery.
CONCLUSIONS:
The current systematic review demonstrates a scarcity of high quality studies on growth delay in children with sleep-disordered breathing. Significant catch-up growth after surgery in the short term and changes in IGF-1, IGFBP-3, ghrelin, and leptin levels has been reported in most published studies.
The availability of high-quality studies on the association between sleep-disordered breathing in children and delayed growth associated with the hormonal profile recorded before surgery and at follow-up is limited.
EVIDENCE ACQUISITION:
Medline PubMed, Scopus and WebOfScience databases were searched for relevant publications published between January 2008 to January 2020 and a total of 261 potentially eligible studies were identified.
EVIDENCE SYNTHESIS:
Following review 19 papers were eligible for inclusion: seven reported a significant post- surgical increase in growth regardless of initial weight status, type of surgery, type of study design, and length of follow-up period. The only high-quality study was a randomized controlled trial that found an increased risk of OSAS relapse in overweight children. Twelve studies reported the significant increase in growth parameters showing that IGF-1, IGFBP-3, and ghrelin may boost growth after surgery.
CONCLUSIONS:
The current systematic review demonstrates a scarcity of high quality studies on growth delay in children with sleep-disordered breathing. Significant catch-up growth after surgery in the short term and changes in IGF-1, IGFBP-3, ghrelin, and leptin levels has been reported in most published studies.
Iris type:
01.01 Articolo in rivista
Keywords:
sleep-related breathing; growth delay; children; systematic review
List of contributors:
LA GRUTTA, Stefania
Published in: