Problem-driven innovations in drug discovery: co-evolution of the patterns of radical innovation with the evolution of problems

Articolo

Data di Pubblicazione:

2016

Abstract:

A fundamentalprobleminthe field oftheproductinnovationmanagementinbiopharmaceutical
industryis how to explainthegeneralsourceofdrugdiscoveryandradicalinnovationsthatsustain
thecompetitiveadvantageof firmsandtechnologicalprogressinmedicine.Thecurrentstudy
confrontsthisproblembydeveloping aconceptualframeworkof problem-driven innovation. The
inductive study,basedonground-breakingdrugsforlungcancertreatment,showsthatthe
perceptionandsolutionofproblemisaninvariant forcethatsupportsthesourceofradical
innovationandevolutionofnewtechnologyinmedicine.Infact,theevolutionofradicalinnovations,
drivenbytheevolutionofconsequentialproblems,isoneofmaindeterminantsthatgeneratesa
technologicalchangeinbiopharmaceuticalandotherindustries.This finding,inaSchumpeterian
world ofinnovation-basedcompetition,isduetotheorganizationalbehaviorofleading firms that
haveastrongincentiveto find innovativesolutionstounsolvedproblemsinordertoachievethe
prospect ofa(temporary)profit monopoly.Themainaimofthisarticleisthereforetoclarifyandto
generalizewheneverpossible,thesourceandevolutionofpath-breakinginnovationsinmedicineto
explainthelong-termtechnologicalchangeinsociety.Thestudyherealsoshowstheimportantrole
of data-sharinghealthpolicyinordertosolveproblemsandpromoteinnovationforbettertherapies
andanefficient "healthcareecosystem".

Tipologia CRIS:

01.01 Articolo in rivista

Keywords:

Product innovation management; Technological paradigm; Target therapy; Radical innovation; Problem solving; Drug discovery

Elenco autori: