Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT)
Academic Article
Publication Date:
2017
abstract:
BackgroundEndocannabinoid anandamide (AEA) inhibits intestinal motility and visceral pain, but it may also be proalgesic through transient receptor potential vanilloid-1 (TRPV1). AEA is degraded by fatty acid amide hydrolase (FAAH). This study explored whether dual inhibition of FAAH and TRPV1 reduces diarrhea and abdominal pain.
Iris type:
01.01 Articolo in rivista
Keywords:
endocannabinoids; fatty acid amide hydrolase; gastrointestinal motility; TRPV cation channels; visceral sensation
List of contributors:
DI MARZO, Vincenzo; Piscitelli, Fabiana
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