HIGH MOBILITY GROUP HMGI(Y) PROTEIN EXPRESSION IN HUMAN COLORECTAL HYPERPLASTIC AND NEOPLASTIC DISEASES
Articolo
Data di Pubblicazione:
2001
Abstract:
HMGI(Y) proteins are overexpressed in experimental and
human malignancies, including colon, prostate and thyroid
carcinomas. To determine at which step of the carcinogenic
process HMGI(Y) induction occurs, we analysed the expression
of the HMGI(Y) proteins in hyperplastic, preneoplastic
and neoplastic tissues of colorectal origin by immunohistochemistry.
All the colorectal carcinomas were HMGI(Y)-positive,
whereas no expression was detected in normal colon
mucosa tissue. HMGI(Y) expression in adenomas was closely
correlated with the degree of cellular atypia. Only 2 of the 18
non-neoplastic polyps tested were HMGI(Y)-positive. These
data indicate that HMGI(Y) protein induction is associated
with the early stages of neoplastic transformation of colon
cells and only rarely with colon cell hyperproliferation.
human malignancies, including colon, prostate and thyroid
carcinomas. To determine at which step of the carcinogenic
process HMGI(Y) induction occurs, we analysed the expression
of the HMGI(Y) proteins in hyperplastic, preneoplastic
and neoplastic tissues of colorectal origin by immunohistochemistry.
All the colorectal carcinomas were HMGI(Y)-positive,
whereas no expression was detected in normal colon
mucosa tissue. HMGI(Y) expression in adenomas was closely
correlated with the degree of cellular atypia. Only 2 of the 18
non-neoplastic polyps tested were HMGI(Y)-positive. These
data indicate that HMGI(Y) protein induction is associated
with the early stages of neoplastic transformation of colon
cells and only rarely with colon cell hyperproliferation.
Tipologia CRIS:
01.01 Articolo in rivista
Elenco autori:
Santoro, Massimo; Fusco, Alfredo; Fedele, Monica
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