New synthesis of PNA-3 ' DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras

A new synthetic strategy to get the PNA-3DNA linker with the monomethoxytrityl
(Mmt) group as temporary protection of the backbone to be used for the synthesis of PNA/DNA
chimeras was employed and a convenient strategy to obtain Mmt PNA monomers was developed.
The synthetic strategies take advantage of the introduction of the acid-labile Mmt-protecting group
in the first step.