Data di Pubblicazione:
2017
Abstract:
Vitamin D may have prognostic value in cardiovascular disease (CVD) patients and,
in addition to conventional biomarkers, could be a valuable tool for disease
management. The aim of this study was to assess the association of vitamin D
status in patients with acute coronary syndrome (ACS) and to evaluate its
prognostic utility. The levels of 25(OH) vitamin D were correlated with troponin
T hs. Forty-eight consecutive outpatients (40 Caucasian and 8 Asian) aged between
40 and 70 years (mean 61.5, range 43-77 years) were enrolled in the study. All
patients were admitted to the Emergency Department with chest pain and suspected
ACS. The main exclusion criteria were age <18 years, kidney failure,
onco-haematological disease, hypo-hyperparathyroidism, hypo/hyperthyroidism,
osteoporosis, treatment with bisphosphonate or 25(OH) vitamin D supplementation.
Of the 48 subjects included in the study, thoracic pain symptoms were described
in 12 patients with unstable angina (UA) and in 6 patients with ST elevation
myocardial infarction (STEMI) and in 30 patients with non-ST-elevation myocardial
infarction (NSTEMI). Low 25(OH) vitamin D levels correlated with the presence of
ACS (p< 0.02) and inversely correlated with Troponin T hs (TnT hs) levels (p<
0.03). The determination of 25(OH) vitamin D levels in combination with TnT hs
could improve the research for possible underlying conditions, and these should
be managed meticulously according to current guidelines.
in addition to conventional biomarkers, could be a valuable tool for disease
management. The aim of this study was to assess the association of vitamin D
status in patients with acute coronary syndrome (ACS) and to evaluate its
prognostic utility. The levels of 25(OH) vitamin D were correlated with troponin
T hs. Forty-eight consecutive outpatients (40 Caucasian and 8 Asian) aged between
40 and 70 years (mean 61.5, range 43-77 years) were enrolled in the study. All
patients were admitted to the Emergency Department with chest pain and suspected
ACS. The main exclusion criteria were age <18 years, kidney failure,
onco-haematological disease, hypo-hyperparathyroidism, hypo/hyperthyroidism,
osteoporosis, treatment with bisphosphonate or 25(OH) vitamin D supplementation.
Of the 48 subjects included in the study, thoracic pain symptoms were described
in 12 patients with unstable angina (UA) and in 6 patients with ST elevation
myocardial infarction (STEMI) and in 30 patients with non-ST-elevation myocardial
infarction (NSTEMI). Low 25(OH) vitamin D levels correlated with the presence of
ACS (p< 0.02) and inversely correlated with Troponin T hs (TnT hs) levels (p<
0.03). The determination of 25(OH) vitamin D levels in combination with TnT hs
could improve the research for possible underlying conditions, and these should
be managed meticulously according to current guidelines.
Tipologia CRIS:
01.01 Articolo in rivista
Keywords:
cardiovascular disease(CVD) acute coronary syndrome(ACS); 25(OH) vitamin D troponin Ths; proc
Elenco autori:
Granato, Teresa
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