The use of VLD (vive la difference) in the molecular-replacement approach: a pipeline

VLD (vive la difference) is a novel ab initio phasing approach
that is able to drive random phases to the correct values. It
has been applied to small, medium and protein structures
provided that the data resolution was atomic. It has never
been used for non-ab initio cases in which some phase
information is available but the data resolution is usually very
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far from 1 A. In this paper, the potential of VLD is tested for
the first time for a classical non-ab initio problem: molecular
replacement. Good preliminary experimental results encour-
aged the construction of a pipeline for leading partial
molecular-replacement models with errors to refined solutions
in a fully automated way. The pipeline moduli and their
interaction are described, together with applications to a wide
set of test cases.