High-energy radiation processing, a smart approach to obtain PVP-graft-AA nanogels.

Poly(N-vinylpyrrolidone)-grafted-acrylic acid biocompatible nanogels(NGs) were prepared using
exiting industrial-type electron accelerator and setups, starting from semi-dilute aqueous solutions
of a commercial PVP and the acrylic acid monomer. As a result, NGs with tunable size and
structure can be obtained quantitatively. Sterility was also impartedat the integrated doseabsorbed.
The chemical structure of the NGs produced was confirmed throughFourier Transformer Infrared
Spectroscopy (FT-IR). The molecular and physico-chemical properties of NGs, such as the
hydrodynamic dimensionsand surface charge densities, at the variance of polymer and monomer
concentrations in the irradiated solutions,are here discussed