Makaluvamine P, a new cytotoxic pyrroloiminoquinone from Zyzzia cf. fuliginosa

A new pyrroloiminoquinone alkaloid (1) belonging to the makaluvamine family has been isolated from the sponge Zyzzya cf. fuliginosa collected in the waters off the Vanuatu Islands. The compound, designated makulavamine P, was characterized on the basis of its spectral data and displayed cytoxicity in the muM range on KB cells and antioxidant activity.