Studies on puupehenone-metabolites of a Dysidea sp.: structure and biological activity.

Puupehenone (1) and a series of its congeners (2-6) have been isolated from a Dysidea sponge. The unprecedented 20-acetoxyhaterumadienone
(2) exhibiting a five-membered contracted ring, has been characterized. In addition, stereochemical assignment of two
previously reported acetone adducts of puupehenone (5 and 6) has been made. Finally, the inhibition of mitochondrial respiratory chain as
well as antibacterial and antifungal activities of all compounds has been evaluated