Determination of losartan and hydrochlorothiazide in tablets by CE and CEC

Capillary electrophoresis (CE) and capillary electrochromatography (CEC)
have been used to determine losartan and hydrochlorothiazide. The CE
separation was carried out in an uncoated capillary filled with a 100 mM
sodium borate pH 9 solution containing trimethyl-beta-cyclodextrin. CEC
was performed using a capillary packed with a RP-18 stationary phase. The
mobile phase was a mixture of 50 mM ammonium acetate pH 7, water and
acetonitrile (1/1.5/7.5). By CE and CEC suitable methods to determine
simultaneously losartan and hydrochlorothiazide in working standard
mixture or pharmaceutical form were obtained. The proposed methods are
very simple and both gave accurate and precise results.