Data di Pubblicazione:
2002
Abstract:
A precise and feasible high-performance liquid chromatographic (HPLC)
method for the analysis of the novel antipsychotic drug quetiapine in
plasma has been developed. The analysis was carried out on a C8 (150x/4.6
mm i.d., 5 micron) reversed-phase column, using a mixture of acetonitrile,
methanol and pH 1.9 phosphate buffer as the mobile phase; triprolidine was
used as the internal standard. Careful pretreatment of the biological
samples was implemented by means of solid-phase extraction (SPE). A good
linearity was found in the 4x400 ng/ml quetiapine plasma concentration
range. The application to some plasma samples of patients treated with
Seroquel tablets gave satisfactory results. The accuracy was good
(quetiapine mean recovery 92%), as well as the precision (mean RSD 3.3%).
The method seems to be suitable for the clinical monitoring of patients
treated with quetiapine.
method for the analysis of the novel antipsychotic drug quetiapine in
plasma has been developed. The analysis was carried out on a C8 (150x/4.6
mm i.d., 5 micron) reversed-phase column, using a mixture of acetonitrile,
methanol and pH 1.9 phosphate buffer as the mobile phase; triprolidine was
used as the internal standard. Careful pretreatment of the biological
samples was implemented by means of solid-phase extraction (SPE). A good
linearity was found in the 4x400 ng/ml quetiapine plasma concentration
range. The application to some plasma samples of patients treated with
Seroquel tablets gave satisfactory results. The accuracy was good
(quetiapine mean recovery 92%), as well as the precision (mean RSD 3.3%).
The method seems to be suitable for the clinical monitoring of patients
treated with quetiapine.
Tipologia CRIS:
01.01 Articolo in rivista
Elenco autori:
Fanali, Salvatore
Link alla scheda completa:
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