Helicobacter pylori immunoproteomes in case reports of rosacea and chronic urticaria

Rosacea and chronic urticaria are two common skin disorders existing in idiopathic forms. A role
of Helicobacter pylori bacterium infection in the aetiopathogenesis of rosacea or chronic urticaria
has been suggested although still controversial. The aim of the present study was to establish a
relationship between H. pylori infection and rosacea chronic urticaria by means of an immunoproteomic investigation. We analyzed immunoglobulin A (IgA)-, IgG-, and IgE-mediated
immune-responses against H. pylori antigens and we identified some bacterial immunoresponsive proteins. A general IgA- and IgE-mediated immune response against antioxidative
bacterial proteins was observed. A correlation between the bacterial occurrence and skin diseases
pathogenesis is discussed.