On the functional and structural characterization of hubs in protein-protein interaction networks
Academic Article
Publication Date:
2013
abstract:
A number of interesting issues have been addressed on biological networks about their global and local properties.
The connection between the topological properties of proteins in Protein-Protein Interaction (PPI)
networks and their biological relevance has been investigated focusing on hubs, i.e. proteins with a large
number of interacting partners. We will survey the literature trying to answer the following questions: Do
hub proteins have special biological properties? Do they tend to be more essential than non-hub proteins?
Are they more evolutionarily conserved? Do they play a central role in modular organization of the protein
interaction network? Are there structural properties that characterize hub proteins?
The connection between the topological properties of proteins in Protein-Protein Interaction (PPI)
networks and their biological relevance has been investigated focusing on hubs, i.e. proteins with a large
number of interacting partners. We will survey the literature trying to answer the following questions: Do
hub proteins have special biological properties? Do they tend to be more essential than non-hub proteins?
Are they more evolutionarily conserved? Do they play a central role in modular organization of the protein
interaction network? Are there structural properties that characterize hub proteins?
Iris type:
01.01 Articolo in rivista
Keywords:
Protein protein interacttion (PPI) networks; Bionformatics
List of contributors:
Guerra, Concettina; Bertolazzi, Paola
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