Data di Pubblicazione:
2011
Abstract:
Objectives: Aim of our study was to evaluate possible signs of the high
capability of the sensori-motor cortex to reorganize the neural circuitry
that is being affected by the disease in nearby areas less affected by
degeneration.
Methods: We studied 16 AD patients and 16 controls by recording from
sensorimotor brain areas their magnetoencephalographic (MEG) fields
at rest and during contralateral median nerve stimulation. Latency
of activation and position of the marker of primary somatosensory
area devoted to hand control were estimated, in addition to spectral
properties of these regions oscillatory activity at rest.
Results: An unambiguous spatial shift of the patients' sensori-motor
generators, with no change in their latencies or strength. Interestingly,
this reorganization appeared more evident in patients with less severe
clinical condition (mini-mental state examination, MMSE, in the 20 25
range), regressing below significant difference from controls with
worsened clinical state (MMSE = 7 20). Low-band activity (delta and theta
bands) increased in patients with a linear behaviour.
Conclusion: More evident signs of cerebral plasticity in AD patients
with less severe clinical damage may suggest that the capability of
sensorimotor regions to reorganize can contribute to the well known
resistance of sensorimotor
capability of the sensori-motor cortex to reorganize the neural circuitry
that is being affected by the disease in nearby areas less affected by
degeneration.
Methods: We studied 16 AD patients and 16 controls by recording from
sensorimotor brain areas their magnetoencephalographic (MEG) fields
at rest and during contralateral median nerve stimulation. Latency
of activation and position of the marker of primary somatosensory
area devoted to hand control were estimated, in addition to spectral
properties of these regions oscillatory activity at rest.
Results: An unambiguous spatial shift of the patients' sensori-motor
generators, with no change in their latencies or strength. Interestingly,
this reorganization appeared more evident in patients with less severe
clinical condition (mini-mental state examination, MMSE, in the 20 25
range), regressing below significant difference from controls with
worsened clinical state (MMSE = 7 20). Low-band activity (delta and theta
bands) increased in patients with a linear behaviour.
Conclusion: More evident signs of cerebral plasticity in AD patients
with less severe clinical damage may suggest that the capability of
sensorimotor regions to reorganize can contribute to the well known
resistance of sensorimotor
Tipologia CRIS:
04.03 Poster in Atti di convegno
Elenco autori:
Tecchio, FRANCA MATILDE; Porcaro, Camillo; Salustri, Carlo
Link alla scheda completa:
Titolo del libro:
Abstracts of the 14th European Congress of Clinical Neurophysiology and the 4th International Conference on Transcranial Magnetic and Direct Current Stimulation.
Pubblicato in: