Methylation of p-tert-butylcalix[8]arene. Products obtained in the presence of strong bases
Academic Article
Publication Date:
1998
abstract:
Methylation of p-tert-butylcalix[8]arene with MeI in the presence of strong bases (NaH, BaO/Ba-
(OH)2, or Cs2CO3) in THF has been investigated. Composition of the reaction mixtures differs
remarkably from those obtained using weak bases and described in a preceding paper. Several
previously unreported methylated products [two dimethoxy- (21,5 and 21,4), a trimethoxy- (31,2,5), a
tetramethoxy- (41,2,3,6), two pentamethoxy- (51,2,3 and 51,2,4), and three hexamethoxy- (61,2, 61,3, and
61,4)] have been isolated. In many cases the substitution pattern was assigned unambiguously on
the basis of spectroscopic evidence only, while in others chemical correlation with known compounds
was required.
(OH)2, or Cs2CO3) in THF has been investigated. Composition of the reaction mixtures differs
remarkably from those obtained using weak bases and described in a preceding paper. Several
previously unreported methylated products [two dimethoxy- (21,5 and 21,4), a trimethoxy- (31,2,5), a
tetramethoxy- (41,2,3,6), two pentamethoxy- (51,2,3 and 51,2,4), and three hexamethoxy- (61,2, 61,3, and
61,4)] have been isolated. In many cases the substitution pattern was assigned unambiguously on
the basis of spectroscopic evidence only, while in others chemical correlation with known compounds
was required.
Iris type:
01.01 Articolo in rivista
List of contributors:
Consoli, GRAZIA MARIA LETIZIA; Cunsolo, Francesca
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