Data di Pubblicazione:
2005
Abstract:
Sodium alginate grafted with low molecular weight polyethylene glycol (PEG) was prepared by reacting a mono-carboxyl terminated PEG
with a sodium alginate modified by inserting a given amount of amine functionalities. The coupling between PEG and alginate was carried
out using carbodiimide chemistry in aqueous solutions. Significant reduction of the molecular weight of alginate is recorded, as expected
from literature reports. The chosen strategy allowed to graft significant amounts of PEG saving the carboxylic functionalities of alginate,
necessary for the cross-linking of the polysaccharide. The chemical structure and chemical-physical properties of alginate derivatives were
characterized by FTIR, 1H and 13C NMR, DSC, TGA and wide angle X-ray analysis.
with a sodium alginate modified by inserting a given amount of amine functionalities. The coupling between PEG and alginate was carried
out using carbodiimide chemistry in aqueous solutions. Significant reduction of the molecular weight of alginate is recorded, as expected
from literature reports. The chosen strategy allowed to graft significant amounts of PEG saving the carboxylic functionalities of alginate,
necessary for the cross-linking of the polysaccharide. The chemical structure and chemical-physical properties of alginate derivatives were
characterized by FTIR, 1H and 13C NMR, DSC, TGA and wide angle X-ray analysis.
Tipologia CRIS:
01.01 Articolo in rivista
Keywords:
Alginate; Polyethyleneglycol; Carbodiimide chemistry; NMR spectroscopy
Elenco autori:
Laurienzo, Paola; Malinconico, Mario; Motta, Andrea
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